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Nevanimibe

Cat. No. M28200

All AbMole products are for research use only, cannot be used for human consumption.

Nevanimibe Structure
Synonym:

PD-132301; ATR-101

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Quality Control & Documentation
Biological Activity

Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer.

Chemical Information
Molecular Weight 421.62
Formula C27H39N3O
CAS Number 133825-80-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Anna Nordenström, et al. Curr Opin Endocrinol Diabetes Obes. Clinical outcomes in 21-hydroxylase deficiency

[2] Phyllis W Speiser. J Clin Endocrinol Metab. Invited Commentary: A Phase 2, Multicenter Study of Nevanimibe for the Treatment of Congenital Adrenal Hyperplasia

[3] Diala El-Maouche, et al. J Clin Endocrinol Metab. A Phase 2, Multicenter Study of Nevanimibe for the Treatment of Congenital Adrenal Hyperplasia

[4] Tao Long, et al. Nature. Structure of nevanimibe-bound tetrameric human ACAT1

[5] David C Smith, et al. Invest New Drugs. A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma

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Keywords: Nevanimibe, PD-132301; ATR-101 supplier, Transferase, inhibitors, activators

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