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Nestorone

Cat. No. M8390

All AbMole products are for research use only, cannot be used for human consumption.

Nestorone Structure
Synonym:

Elcometrine; Nestorone; ST-1435

Size Price Availability Quantity
5mg USD 50 In stock
10mg USD 80 In stock
25mg USD 160 In stock
50mg USD 250 In stock
100mg USD 350 In stock
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Quality Control & Documentation
Biological Activity

Nestorone is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. Nestorone has been used as a female contraceptive, and recent studies inidicate that it may be useful as a male contraceptive as well. It has also been shown to have neurogenic and neuroprotective activity.

Chemical Information
Molecular Weight 370.48
Formula C23H30O4
CAS Number 7759-35-5
Form Solid
Solubility (25°C) DMSO: 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Magalie Frchou, et al. Sex differences in the cerebroprotection by Nestorone intranasal delivery following stroke in mice

[2] Martine El-Etr, et al. Nestorone ® , a 19nor-progesterone derivative boosts remyelination in an animal model of demyelination

[3] Julian P Tuazon, et al. Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic

[4] Motoki Tanaka, et al. Nestorone exerts long-term neuroprotective effects against transient focal cerebral ischemia in adult male rats

Related Progesterone Receptor Products
Dienogest

Dienogest is an orally-active semisynthetic, steroidal progestogen (or progestin).

Gestodene

Gestodene is a synthetic progestin used as a contraceptive.

Altrenogest

Altrenogest is a progestogen structurally related to veterinary steroid trenbolone.

Dydrogesterone

Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.

Ethynodiol diacetate

Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

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Keywords: Nestorone, Elcometrine; Nestorone; ST-1435 supplier, Progesterone Receptor, inhibitors, activators

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