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Nemorexant hydrochloride is an orally active dual orexin type 1 and type 2 (OX1 and OX2) receptor antagonist (DORA) as well as an inhibitor of BCRP, with an IC50 value of 3.0 μM when acting on BCRP, and can be used in studies related to insomnia.
| Molecular Weight | 487.39 |
| Formula | C23H24Cl2N6O2 |
| CAS Number | 1792993-84-0 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Am J Health Syst Pharm. Daridorexant Hydrochloride
| Related OX Receptor Products |
|---|
| MK-6096
MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R. |
| Almorexant
Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. |
| SB408124
SB408124 (Tocris-1963) is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. |
| MK-3697
MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. |
| TCS-1102
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). |
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