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Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH).
| Molecular Weight | 624.77 |
| Formula | C38H44N2O6 |
| CAS Number | 2292-16-2 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage | 4°C |
[5] Shibu Marthandam Asokan, et al. Pharmacological benefits of neferine - A comprehensive review
| Related NF-κB Products |
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| QNZ
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| Caffeic Acid Phenethyl Ester
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| Cepharanthine
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| JSH-23
Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| Methylthiouracil
Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
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