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Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction.
| Molecular Weight | 470.01 |
| Formula | C25H32ClN5O2 |
| CAS Number | 83366-66-9 |
| Form | Oil |
| Solubility (25°C) | DMSO 125 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Nefazodone
[2] No authors listed. Nefazodone
[3] No authors listed. Nefazodone
[4] M Cyr, et al. Ann Pharmacother. Nefazodone: its place among antidepressants
[5] V L Ellingrod, et al. Am J Health Syst Pharm. Nefazodone: a new antidepressant
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