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NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH.
| Molecular Weight | 395.45 |
| CAS Number | 1542213-00-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PHGDH Products |
|---|
| CBR 5884
CBR 5884 is a 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor. |
| NCT-503
NCT-503 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first, rate-limiting step of glucose-derived serine synthesis. |
| BI-4916
BI-4916 is a precursor of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor. |
| BI-4924
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. |
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