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NCOA4-9a (NCOA4-FTH1 inhibitor 9a) is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. NCOA4-9a effectively blocks RSL3-induced ferroptosis in HT22 cells (EC50 = 3.66 μM).
NCOA4-9a directly binds to recombinant protein NCOA4383–522 (Kd=7.48 uM) and effectively blocks the NCOA4383–522–FTH1 interaction. NCOA4-9a is a selective ferroptosis inhibitor that effectively suppresses lipid peroxidation and rescues cells from ferroptosis. NCOA4-9a inhibits lysosomal ferritin degradation and localizes in autophagosomes.
NCOA4-9a significantly ameliorates the ischemic-refusion injury in rat model of ischemic stroke.
| Molecular Weight | 441.54 |
| Formula | C27H28FN5 |
| CAS Number | 2650557-72-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C |
| Related Ferroptosis Products |
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| Sulfasalazine
Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. |
| Deferiprone
Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| Erastin
Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended |
| Ferrostatin-1
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| Lithocholic acid
Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption, can also activate the vitamin D receptor. |
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