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NBI-98782

Cat. No. M14234

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NBI-98782 Structure
Synonym:

(+)-DTBZ; (+)-α-Dihydrotetrabenazine; (+)-α-DHTBZ

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Quality Control & Documentation
Biological Activity

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM. IC50 value: 0.97± 0.48 nM Target: VMAT2 The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection.

Chemical Information
Molecular Weight 319.44
CAS Number 85081-18-1
Solubility (25°C) DMSO 33.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mei Huang, et al. Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action

[2] Rosa Luo, et al. Single Dose and Repeat Once-Daily Dose Safety, Tolerability and Pharmacokinetics of Valbenazine in Healthy Male Subjects

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Keywords: NBI-98782, (+)-DTBZ; (+)-α-Dihydrotetrabenazine; (+)-α-DHTBZ supplier, Monoamine Oxidase, inhibitors, activators

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