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NB-360 

Cat. No. M28091

All AbMole products are for research use only, cannot be used for human consumption.

NB-360  Structure

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Quality Control & Documentation
Biological Activity

NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E.

Chemical Information
Molecular Weight 449.4
Formula C21H19F4N5O2
CAS Number 1262857-73-7
Form Solid
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Silvio R Meier, et al. J Nucl Med. 11C-PiB and 124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention

[2] Heinrich Rueeger, et al. J Med Chem. Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360

[3] Alvaro Miranda, et al. J Alzheimers Dis. Selective Secretase Targeting for Alzheimer's Disease Therapy

[4] Ulf Neumann, et al. Br J Pharmacol. The β-secretase (BACE) inhibitor NB-360 in preclinical models: From amyloid-β reduction to downstream disease-relevant effects

[5] Ulf Neumann, et al. Mol Neurodegener. A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

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  Catalog
Abmole Inhibitor Catalog




Keywords: NB-360  supplier, Gamma-secretase/Beta-secretase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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