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NAS-181

Cat. No. M7017

All AbMole products are for research use only, cannot be used for human consumption.

NAS-181 Structure

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Biological Activity

NAS-181 is a potent, selective antagonist at the rat 5-HT1B receptor (Ki = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo. Increases subthalamic nucleus-triggered complex EPSCs and burst firing in SNr GABA neurons

Chemical Information
Molecular Weight 538.63
Formula C19H26N2O4.2CH3SO3H
CAS Number 1217474-40-2
Solubility (25°C) Water 53.86 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Pini, et al. J Pharmacol Exp Ther. Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor.

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Keywords: NAS-181 supplier, inhibitors, activators

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