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Naquotinib(ASP8273)

Cat. No. M20622

All AbMole products are for research use only, cannot be used for human consumption.

Naquotinib(ASP8273) Structure

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Quality Control & Documentation
Biological Activity

Naquotinib(ASP8273) is an orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.

Chemical Information
Molecular Weight 562.71
Formula C30H42N8O3
CAS Number 1448232-80-1
Solubility (25°C) DMSO 52 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mohamed W Attwa, et al. RSC Adv. Reactive intermediates in naquotinib metabolism identified by liquid chromatography-tandem mass spectrometry: phase I metabolic profiling

[2] Misako Nagasaka, et al. J Thorac Oncol. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC

[3] Hiroaki Tanaka, et al. Leuk Res. Naquotinib exerts antitumor activity in activated B-cell-like diffuse large B-cell lymphoma

[4] Ayesha Murtuza, et al. Cancer Res. Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung Cancer

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Keywords: Naquotinib(ASP8273) supplier, EGFR/HER2, inhibitors, activators

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