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Namodenoson (also known as 2-Cl-IB-MECA and CF-102) is an orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist (Ki=0.33 nM) with potential antineoplastic activity. Namodenoson selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. In human ADF cells of astroglial lineage, 100 nM Namodenoson (2-Cl-IB-MECA) caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions.
In vivo, administration of 200 μg/kg Namodenoson (2-Cl-IB-MECA) resulted in a short-lasting hypotension, which was accompanied by a 50-100-fold increase in plasma histamine concentrations.
| Molecular Weight | 544.73 |
| Formula | C18H18ClIN6O4 |
| CAS Number | 163042-96-4 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Adenosine Receptor Products |
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CGS 21680 hydrochloride is an A2A adenosine receptor agonist with an Ki of 27 nM. |
| Istradefylline
Istradefylline (KW-6002) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. |
| CGS 21680
CGS 21680 is a selective adenosine receptor agonist for A2A and A3 with Ki of 15 ng/mL and 37 ng/mL, respectively. |
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Norisoboldine is an isoquinoline alkaloid which acts as an AhR agonist. |
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