All AbMole products are for research use only, cannot be used for human consumption.
Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis.
Immobilized human GM CSF at 2 ug/mL can bind Namilumab, the EC50 is 0.008075 ug/mL.
| CAS Number | 1206681-39-1 |
| Gene ID | 1437 [NCBI] |
| Storage | Store at ≤ -70°C for 2 years. Avoid multiple freeze-thaws. |
[1] John G Rizk, et al. Drugs. Pharmaco-Immunomodulatory Therapy in COVID-19
[2] Sarah Onuora. Nat Rev Rheumatol. Namilumab improves RA symptoms
| Related CSF-1R (c-Fms) Products |
|---|
| GW2580
GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. |
| PLX647
PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively. |
| BLZ945 (Sotuletinib)
Sotuletinib (BLZ945) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs. |
| Ki 20227
Ki 20227 is a c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation. |
| PLX5622
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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