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Naldemedine (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA). Naldemedine shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors. Naldemedine can be used in opioid-induced constipation (OIC) research. Naldemedine is predicted to bind to 3CLpro encoded by SARS-CoV2 genome.
| Molecular Weight | 570.64 |
| Formula | C32H34N4O6 |
| CAS Number | 916072-89-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Flaminia Coluzzi, et al. J Pain Res. Naldemedine: A New Option for OIBD
[3] No authors listed. Naldemedine
[4] Hannah A Blair. Drugs. Naldemedine: A Review in Opioid-Induced Constipation
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