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Naldemedine tosylate

Cat. No. M28208

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Naldemedine tosylate Structure
Synonym:

S-297995 tosylate

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Quality Control & Documentation
Biological Activity

Naldemedine (S-297995) tosylate is an orally active μ-opioid receptor antagonist (PAMORA). Naldemedine tosylate shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors. Naldemedine can be used in opioid-induced constipation (OIC) research. Naldemedine tosylate is predicted to bind to 3CLpro encoded by SARS-CoV2 genome.

Chemical Information
Molecular Weight 742.84
Formula C39H42N4O9S
CAS Number 1345728-04-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] No authors listed. Drug Ther Bull. Naldemedine for opioid-induced constipation

[2] Junya Sato, et al. Support Care Cancer. A preliminary study of the effect of naldemedine tosylate on opioid-induced nausea and vomiting

[3] Ryosuke Watari, et al. Drug Metab Pharmacokinet. Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist

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Keywords: Naldemedine tosylate, S-297995 tosylate supplier, Opioid Receptor, inhibitors, activators

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