All AbMole products are for research use only, cannot be used for human consumption.
Naftopidil (Flivas) is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM. Naftopidil (Flivas) is an antihypertensive agent. Naftopidil (Flivas) binds specifically to alpha 1-adrenoceptors. The Ki values are 58.3 nM for naftopidil, 0.43 nM for prazosin, and 197 nM for urapidil. The affinities of naftopidil to alpha 2- and beta-adrenoceptor sites are very low (> 6,000 and > 2,500 nM). Naftopidil relaxes aortic strips precontracted with norepinephrine concentration-dependently, and naftopidil (Flivas) shifts the concentration-response curve of norepinephrine in a parallel manner to the right. The pA2 values are 7.10 for naftopidil, 8.85 for prazosin, and 6.25 for urapidil.
| Molecular Weight | 392.49 |
| Formula | C24H28N2O3 |
| CAS Number | 57149-07-2 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Adrenergic Receptor Products |
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| Tamsulosin hydrochloride
Tamsulosin is a new, highly selective α1A-adrenoceptor antagonist. |
| Mirabegron
Mirabegron (YM178) is a potent and selective β(3)-adrenoceptor agonist with EC50 of 22.4 nM. |
| Detomidine hydrochloride
Detomidine hydrochloride is a nonnarcotic, synthetic alpha-2 adrenoreceptor agonist. |
| (R)-(+)-Atenolol
(R)-(+)-Atenolol binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. |
| Reboxetine mesylate
Reboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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