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Nafcillin sodium monohydrate is an antibiotic, it reversibly inhibits β-lactamase with Kd of 33 mM. Nafcillin sodium monohydrate (100 mg/kg; s.c.) exhibits bactericidal activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), with MICs of 0.5 μg/mL and 64.0 μg/mL for S. aureus strains Xen-29 and Xen-1, respectively, in mice. Nafcillin sodium monohydrate can be used for the research of staphylococcal infections.
| Molecular Weight | 454.47 |
| Formula | C21H21N2O5S.H2O.Na |
| CAS Number | 7177-50-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, dry, sealed |
[1] Parthvi Rukma, et al. Nafcillin-Associated Hypokalemia
[4] A F North Jr, et al. Sodium nafcillin in the treatment of Group A streptococcal infections
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