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NAB-14 

Cat. No. M28014

All AbMole products are for research use only, cannot be used for human consumption.

NAB-14  Structure

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Quality Control & Documentation
Biological Activity

NAB-14 is a potent, selective, orally active and non-competitive GluN2C/2D antagonists with an IC50 of 580 nM for GluN1/GluN2D. NAB-14 shows >800-fold selective for recombinant GluN2C and GluN2D over GluN2A and GluN2B. NAB-14 can cross the blood-brain-barrier.

Chemical Information
Molecular Weight 351.4
Formula C20H21N3O3
CAS Number 1237541-73-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Samantha L Summer, et al. ACS Med Chem Lett. Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor

[2] Sharon A Swanger, et al. ACS Chem Neurosci. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons

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Keywords: NAB-14  supplier, GluR, inhibitors, activators

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