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NA-17

Cat. No. M8605

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NA-17 Structure

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Biological Activity

NA-17 is a fluorescent naphthalimide that induces accumulation of activated p53 in mitochondria and nuclei of NSCLC cells. NA-17 reorganizes the Bak–Bcl-xl complex, promotes p53 phosphorylation without altering the expression of p53, induces cell cycle arrest at the G1 phase and apoptosis. NA-17 exhibits potent anticancer activities in multiple cancer cell lines showing low toxicity to normal cell lines.

Chemical Information
Molecular Weight 445.51
Formula C26H27N3O4
CAS Number 1708948-28-0
Solubility (25°C) DMSO: 5 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hai-Ying Wang, et al. Sandwich-Type Uranyl Phosphate-Polyoxometalate Cluster Exhibiting Strong Luminescence

[2] Guohai Zhang, et al. Mitochondrion-Targeting Identification of a Fluorescent Apoptosis-Triggering Molecule by Mass Spectrometry Elucidates Drug Tracking

[3] Guohai Zhang, et al. A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak·Bcl-xl Complex and Triggering Transcriptional Regulation

[4] Israel M Mbomekalle, et al. Structure, magnetism, and electrochemistry of the multinickel polyoxoanions [Ni6As3W24O94(H2O)2]17-, [Ni3Na(H2O)2(AsW9O34)2]11-, and [Ni4Mn2P3W24O94(H2O)2]17-

[5] Laurent Ruhlmann, et al. Di- and tricobalt Dawson sandwich complexes: synthesis, spectroscopic characterization, and electrochemical behavior of Na(18)[(NaOH(2))(2)Co(2)(P(2)W(15)O(56))(2)] and Na(17)[(NaOH(2))Co(3)(H(2)O)(P(2)W(15)O(56))(2)]

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Keywords: NA-17 supplier, inhibitors, activators

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