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N-Methylisatoic anhydride

Cat. No. M27674

All AbMole products are for research use only, cannot be used for human consumption.

N-Methylisatoic anhydride Structure
Synonym:

NMIA

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Quality Control & Documentation
Biological Activity

N-Methylisatoic anhydride (NMIA) is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology.

Chemical Information
Molecular Weight 177.16
Formula C9H7NO3
CAS Number 10328-92-4
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jaime F Martínez Suárez, et al. J Org Chem. Electrosynthesis of N-Methylisatin

[2] S Ursuegui, et al. Chem Commun (Camb). Biotin-conjugated N-methylisatoic anhydride: a chemical tool for nucleic acid separation by selective 2'-hydroxyl acylation of RNA

[3] M A Faner, et al. Methods. Identifying and characterizing Hfq-RNA interactions

[4] P L DeAngelis. Anal Biochem. Polysaccharide labeling with N-methylisatoic anhydride: generation of ultraviolet chromophores and blue fluorophores

[5] A Mehra, et al. Indian J Biochem Biophys. Analysis of amino acid mixtures after pre-column derivatisation by N-methylisatoic anhydride using HPLC

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Keywords: N-Methylisatoic anhydride, NMIA supplier, inhibitors, activators

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