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N-Desethyl Sunitinib is a major and pharmacologically active metabolite of the tyrosine kinase inhibitor and anticancer compound Sunitinib. Sunitinib also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib exhibits antiangiogenic and antitumor activity in multiple xenograft models.
| Molecular Weight | 370.42 |
| Formula | C20H23FN4O2 |
| CAS Number | 356068-97-8 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| N-Desmethyl Imatinib
N-Desmethyl Imatinib |
| Desthiazolylmethyloxycarbonyl Ritonavir
Desthiazolylmethyloxycarbonyl Ritonavir is a metabolite of Ritonavir, which is a HIV protease inhibitor. |
| 4-Hydroxy phenyl carvedilol
4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker. |
| Omeprazole sulfone
Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor. |
| Duloxetine Phenolic Impurity
Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI). |
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