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MYC-IN-3 is a potent MYC inhibitor. MYC-IN-3 shows antiproliferative and anticancer activity. MYC-IN-3 inhibits the binding of MYC/MYC-associated protein X (MAX) heterodimer to DNA consensus sequence, induce MYC thermal instability, and disturb MYC/MAX interaction. MYC-IN-3 exhibited superior antiproliferative activities to those of MYCi975 against multiple malignant cell lines. It induced dose-dependent MYC degradation in cells with degradation observed at the concentration as low as 1.0 μM.
MYC-IN-3 demonstrated enhanced therapeutic efficacy over MYCi975 in a mouse allograft model of prostate cancer. MYC-IN-3 can be used in the research of prostate cancer.
| Molecular Weight | 543.89 |
| Formula | C25H20ClF6N3O2 |
| CAS Number | 3042878-82-7 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | Powder -20°C |
| Related c-Myc Products |
|---|
| 10058-F4
10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. |
| 10074-G5
10074-G5 is a c-Myc/Max interaction inhibitor, which binds to a different specific binding site (region) of C-Myc than 10054-F4. |
| ML327
ML327 is a blocker of MYC, which mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition. |
| MYCi975
MYCi975 (Nuc-0200975) is an orally active MYC inhibitor that disrupts MYC/MAX interactions, promotes MYC T58 phosphorylation and MYC degradation, and impairs myC-driven gene expression. MYCi975 (NUC-0200975) has strong anti-tumor effect and good tolerance, increasing tumor immune cell infiltration and enhancing tumor sensitivity against PD1 immune studies. |
| APTO-253
APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. |
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Products are for research use only. Not for human use. We do not sell to patients.
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