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MTX-531 is a first-in-class, potent and selective inhibitor of EGFR and PI3K, with IC50s of 14.7 nM and 1.1-233 nM (differ in subtype). MTX-531 can also act as a weak agonist of PPARγ, with the EC50 of 3.4 μM in 293H cells. MTX-531 inhibits EGFR and PI3K-mTOR signaling and tumor growth in the HNSCC PDX model.
| Molecular Weight | 453.94 |
| Formula | C22H20ClN5O2S |
| CAS Number | 2791417-66-6 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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