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MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM) and a partial agonist at human MC3 and MC5 receptors (EC50 values of 59 and 1300 nM, respectively). In addition, MSG606 TFA reversed the hyperalgesia induced in female mice but had no effect in male mice.
| Molecular Weight | 1461.53 |
| Formula | C63H83F3N20O15S |
| CAS Number | 1416983-77-1 (free base) |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Melanocortin Receptor Products |
|---|
| α-MSH
α-MSH (α-Melanocyte-stimulating hormone) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. |
| Melanotan I acetate
Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH). *This compound is unstable in solutions, freshly prepared is recommended. |
| Setmelanotide
Setmelanotide is a selective agonist of the MC4 receptor, with EC50 values of 0.27 nM and 0.28 nM for human and rat MC4R, respectively. |
| Bremelanotide Acetate
Bremelanotide Acetate (PT-141 Acetate) is a peptide containing seven amino acids and is also a macrocyclic compound. In addition, Bremelanotide Acetate is an agonist of the melanocortin 4 receptor (MC4R). |
| JNJ-10229570
JNJ-10229570 (UNII-N9IX402L35) is is a novel MC1R and MC5R antagonist, which inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R with IC50 values of 270 nM and 200 nM, respectively. |
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