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MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.
| Molecular Weight | 398.45 |
| Formula | C22H26N2O5 |
| CAS Number | 423748-02-1 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Chunyan Ren, et al. Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain
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