All AbMole products are for research use only, cannot be used for human consumption.
MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. MRTX849 (Adagrasib) maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. MRTX849 (Adagrasib) exhibited significantly improved half-life and penetration into the tumor, shutting down KRAS signaling for the entire dosing interval, and showing a higher degree of antitumor activity than previous KRAS mutant-selective inhibitors.
iScience. 2023 Jan 28;26(2):106080..
Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
MRTX849 (Adagrasib) purchased from AbMole
| Molecular Weight | 604.12 |
| Formula | C32H35ClFN7O2 |
| CAS Number | 2326521-71-3 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage | -20°C, dry, sealed |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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