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Momordin-Ic is a SENP1 Inhibitor. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction. Momordin Ic is a principal saponin constituent of Kochia scoparia L. Schrad. with anti-cancer bioactivity.
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Source | Oncotarget (2016). Figure 2. Momordin-Ic |
| Method | western blot | |
| Cell Lines | PC3 cells | |
| Concentrations | 50 μM | |
| Incubation Time | 24 h | |
| Results | Flag-SENP1 accumulation markedly increased as Mc concentration increased. |
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Source | Oncotarget (2016). Figure 1. Momordin-Ic |
| Method | SENP1 activity assay | |
| Cell Lines | PC3 cells | |
| Concentrations | 25 μM | |
| Incubation Time | 24 h | |
| Results | The accumulation of SUMO-modified proteins increased as the Mc treatment concentration increased, indicating that Mc inhibits the isopeptidase activity of full-length SENP1 in cells. |
| Cell Experiment | |
|---|---|
| Cell lines | HepG2 cells |
| Preparation method | Hydrogen peroxide specically reacts with DCFH-DA, which oxidizes DCFH to the uorescent DCF. Cells were treated with 10 mM DCFH-DA at 37 C for 30 min aer momordin Ic incubation, and uorescence was detected by ow cytometry. |
| Concentrations | 10 μM |
| Incubation time | 4 h |
| Animal Experiment | |
|---|---|
| Animal models | male nude mice (Balb/c) |
| Formulation | DMSO |
| Dosages | 10 mg/kg |
| Administration | i.p. |
| Molecular Weight | 764.94 |
| Formula | C41H64O13 |
| CAS Number | 96990-18-0 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | 2-8°C, protect from light |
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