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Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma for patients unresponsive to less potent corticosteroids, and penile phimosis. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone. Mometasone furoate reduces inflammation by causing several effects: reversing the activation of inflammatory proteins, activating the secretion of anti-inflammatory proteins, stabilising cell membranes, decreasing the influx of inflammatory cells.
| Molecular Weight | 521.43 |
| Formula | C27H30Cl2O6 |
| CAS Number | 83919-23-7 |
| Solubility (25°C) | DMSO 6 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Howraman Meteran, et al. Mometasone furoate nasal spray for the treatment of asthma
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| Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist that induces the production of phospholipase A2 inhibitory protein.It can be used to construct models of allergic conjunctivitis. |
| Budesonide
Budesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Budesonide is also a DNA methyltransferase activator. |
| AZD5423
AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. |
| Hydrocortisone
Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
| Meprednisone
Meprednisone is a glucocorticoid and a methylated derivative of prednisone. |
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