Free shipping on all orders over $ 500

MN58b

Cat. No. M11210

All AbMole products are for research use only, cannot be used for human consumption.

MN58b Structure
Size Price Availability Quantity
1mg USD 240 In stock
5mg USD 320 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

MN58b is a selective inhibitor of choline kinase α (CHKα) and inhibits phosphocholine synthesis. MN58b induces apoptosis to reduce cell growth. MN58b also has antitumoral activity.

In vivo, MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.

Chemical Information
Molecular Weight 640.49
Formula C32H40Br2N4
CAS Number 203192-01-2
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Stefanie Marek-Iannucci, et al. JCI Insight. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis

[2] Tahl Zimmerman, et al. Sci Rep. Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae

[3] Elsa Sanchez-Lopez, et al. Cell Metab. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

[4] Jose M Mazarico, et al. Mol Cancer Ther . Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors

[5] M Guma, et al. Ann Rheum Dis. Choline kinase inhibition in rheumatoid arthritis

[6] Nada M S Al-Saffar, et al. Cancer Res . Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

[7] Nada M S Al-Saffar, et al. Cancer Res. Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

Related Apoptosis Products
23-Hydroxybetulinic acid

23-Hydroxybetulinic acid is a novel anticancer substance.
TH-302 (Evofosfamide)

TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM.
Se-Methylselenocysteine

Se-methylselenocysteine, a precursor of methyl selenium, has strong cancer chemoprophylaxis and antioxidant activity. Se-Methylselenocysteine has oral biological activity, can induce apoptosis.
Aloperine

Aloperine is exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
Ezatiostat

Ezatiostat (TER199, TLK199) is a glutathione analog inhibitor of glutathione S-transferase (GST) P1-1. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation.
  Catalog
Abmole Inhibitor Catalog




Keywords: MN58b supplier, Apoptosis, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.