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MMI-0100

Cat. No. M21660

All AbMole products are for research use only, cannot be used for human consumption.

MMI-0100 Structure

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Biological Activity

MMI-0100 is a novel cell permeant peptide inhibitor of Mitogen Activated Protein Kinase Activated Protein Kinase II (MK2), MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease. MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 caused sodium nitroprusside induced smooth muscle cell relaxation and inhibited intimal thickening in human saphenous vein rings in a dose-dependent fashion.

In a murine aortic bypass model, MMI-0100 reduced intimal thickness in vein grafts by 72%, and there were fewer F4/80-reactive cells in vein grafts treated with MMI-0100. MMI-0100 prevents vein graft intimal thickening ex vivo and in vivo.

Chemical Information
Molecular Weight 2283.64
Formula C98H171N37O26
CAS Number 1039342-24-9
Solubility (25°C) Water ≥ 70 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] JinHong Jiang, et al. Front Immunol. Intranasal MMI-0100 Attenuates Aβ1-42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

[2] Zhe Wang, et al. Molecules. MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway

[3] Binchan He, et al. Drug Des Devel Ther. MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1

[4] Qinghang Meng, et al. J Am Heart Assoc. MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

[5] Lei Xu, et al. J Mol Cell Cardiol. MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

[6] Akihito Muto, et al. Vascul Pharmacol. Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo

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Keywords: MMI-0100 supplier, inhibitors, activators

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