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MMB-4

Cat. No. M8427

All AbMole products are for research use only, cannot be used for human consumption.

MMB-4 Structure

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Quality Control & Documentation
Biological Activity

MMB-4 is an oxime that can reactivate cholinesterases that have been inactivated by exposure to organophosphates such as sarin or soman. Administration of MMB-4 and atropine normalizes many respiratory parameters in guinea pigs following soman inhalation.

Chemical Information
Molecular Weight 418.08
Formula C13H14N4O2 · 2Br
CAS Number 2058-89-1
Solubility (25°C) Water: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Michael W Perkins, et al. Aerosolized delivery of oxime MMB-4 in combination with atropine sulfate protects against soman exposure in guinea pigs

[2] Paul M Lundy, et al. Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning

[3] Franz Worek, et al. Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach

[4] Patrick Macauley, et al. Chromatographic separation and NMR characterization of the isomers of MMB-4, a bis-(pyridiniumaldoxime)

[5] C L Woodard, et al. MMB-4 pharmacokinetics in rabbits after intravenous and intramuscular administration

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Keywords: MMB-4 supplier, inhibitors, activators

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