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MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 768.42 |
| CAS Number | 1415246-68-2 |
| Solubility (25°C) | DMSO 27 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Related Microtubule Products |
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Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
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