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he linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 compound moieties per antibody molecule.
 |
Source | Ther Adv Respir Dis (2018). Figure 3. MMAD |
| Method | Influence of inhalation duration on lung deposition | |
| Cell Lines | mice | |
| Concentrations | 1.5, 3.0, 4.5 μM | |
| Incubation Time | - | |
| Results | Other studies also suggest that particles with an MMAD in the range 1.5–4.5 μm can achieve good lung deposition, consistent with these findings. |
| Molecular Weight | 771.06 |
| Formula | C41H66N6O6S |
| CAS Number | 203849-91-6 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Paul Zarogoulidis, et al. Modification Tadalafil and Macitentan tablets to aerosol
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