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MLT-747 

Cat. No. M29223

All AbMole products are for research use only, cannot be used for human consumption.

MLT-747  Structure

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Quality Control & Documentation
Biological Activity

MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM.

Chemical Information
Molecular Weight 478.33
Formula C20H21Cl2N7O3
CAS Number 2097853-86-4
Form Solid
Storage 4°C, protect from light
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MALT1 inhibitor MI-2 is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.

MLT-748

MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM.

JNJ-67856633

Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective mucosa-associated lymphoid tissue protein 1 (MALT1) allosteric inhibitor for studies related to chronic lymphocytic leukemia (CLL).

MLT-943

MLT-943 is a potent, selective, and orally active inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1) that inhibits IL-2 secretion in PBMC or whole blood with IC50 values of 0.07-0.09 μM and 0.6-0.8 μM, respectively.In addition, MLT-943 possesses anti-inflammatory activity and can be used in studies of FcgR-mediated inflammation .

SGR-1505

SGR-1505 is an oral potent small molecule allosteric inhibitor of MALT1 that inhibits MALT1 enzymatic activity and demonstrates anti-proliferative activity in ABC-DLBCL cell lines, both BTKi-sensitive (OCI-LY10) and BTKi-resistant (OCI-LY3). SGR-1505 can be used in studies related to B-cell tumors.

  Catalog
Abmole Inhibitor Catalog




Keywords: MLT-747  supplier, MALT1, inhibitors, activators

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