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MLR-1023

Cat. No. M8311

All AbMole products are for research use only, cannot be used for human consumption.

MLR-1023 Structure
Synonym:

Tolimidone

Size Price Availability
5mg USD 50 Out of stock
25mg USD 160 Out of stock
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Quality Control & Documentation
Biological Activity

MLR-1023 (Tolimidone) is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase that produces lasting glucose lowering, reduces HbA1c levels, and preserves pancreatic β-cells in db/db mice. MLR-1023 increased insulin receptor sensitivity. MLR-1023 (Tolimidone) is antiulcer agent.

Chemical Information
Molecular Weight 202.21
Formula C11H10N2O2
CAS Number 41964-07-2
Form Solid
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Candida J Rebello, et al. MLR-1023 Treatment in Mice and Humans Induces a Thermogenic Program, and Menthol Potentiates the Effect

[2] Moon-Kyu Lee, et al. A novel non-PPARgamma insulin sensitizer: MLR-1023 clinicalproof-of-concept in type 2 diabetes mellitus

[3] Michael S Saporito, et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo

[4] Alexander R Ochman, et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes

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Keywords: MLR-1023, Tolimidone supplier, Src-bcr-Abl, inhibitors, activators

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