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ML753286

Cat. No. M14186

All AbMole products are for research use only, cannot be used for human consumption.

ML753286 Structure

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Quality Control & Documentation
Biological Activity

ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species.

Chemical Information
Molecular Weight 355.43
CAS Number 1699720-89-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Pu Shi, et al. Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles

[2] Mingxiang Liao, et al. Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP)

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  Catalog
Abmole Inhibitor Catalog




Keywords: ML753286 supplier, BCRP/ABCG2/MXR/ABCP, inhibitors, activators

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