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ML381

Cat. No. M28713

All AbMole products are for research use only, cannot be used for human consumption.

ML381 Structure
Synonym:

VU0488130

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Quality Control & Documentation
Biological Activity

ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies.

Chemical Information
Molecular Weight 379.41
Formula C21H21N3O4
CAS Number 1623481-80-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Naoya Aoki, et al. Behav Brain Res. Subtype-selective contribution of muscarinic acetylcholine receptors for filial imprinting in newly-hatched domestic chicks

[2] Patrick R. Gentry, et al. Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity

[3] Patrick R Gentry, et al. ChemMedChem. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

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Keywords: ML381, VU0488130 supplier, AChR/AChE, inhibitors, activators

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