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ML352 

Cat. No. M28777

All AbMole products are for research use only, cannot be used for human consumption.

ML352  Structure

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Quality Control & Documentation
Biological Activity

ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Ki values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively.

Chemical Information
Molecular Weight 387.47
Formula C21H29N3O4
CAS Number 1649450-12-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jeanette L Bertron, et al. Bioorg Med Chem Lett. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound

[2] Sean R Bollinger, et al. Bioorg Med Chem Lett. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter

[3] Elizabeth A Ennis, et al. ACS Chem Neurosci. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter

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Keywords: ML352  supplier, AChR/AChE, inhibitors, activators

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