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ML336 

Cat. No. M28684

All AbMole products are for research use only, cannot be used for human consumption.

ML336  Structure

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Quality Control & Documentation
Biological Activity

ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range.

Chemical Information
Molecular Weight 367.4
Formula C19H21N5O3
CAS Number 1613465-33-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jasper Lee, et al. J Virol. Emergence and Magnitude of ML336 Resistance in Venezuelan Equine Encephalitis Virus Depend on the Microenvironment

[2] Andrew M Skidmore, et al. Antiviral Res. Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production

[3] Colleen B Jonsson, et al. Antiviral Res. Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses

[4] Annette E LaBauve, et al. Sci Rep. Lipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection

[5] Donghoon Chung, et al. ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV)

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Keywords: ML336  supplier, Anti-infection, inhibitors, activators

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