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CID-1067700 (ML282) is a competitive inhibitors of nucleotide binding by Ras-related GTPases with a Ki of 13 nM for Rab7. CID-1067700 (ML282) preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively. CID-1067700 (0-40 μM) inhibits Rab7 activity, NF-κB activation as well as AID induction in B cells.
In vivo, CID-1067700 (16 mg/kg; i.p.) prevents disease development in lupus-prone mice by Rab7 inhibition, and reduces IgG-IC deposition in MRL/Faslpr/lpr mice.
| Molecular Weight | 390.48 |
| Formula | C18H18N2O4S2 |
| CAS Number | 314042-01-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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