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ML169

Cat. No. M8266

All AbMole products are for research use only, cannot be used for human consumption.

ML169 Structure

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Biological Activity

ML169 is a positive allosteric modulator (PAM) of the muscurinic acetycholine receptor M1 (CHRM1). ML169 does not cross react with other muscarinic receptors and is able to penetrate the blood brain barrier.

Chemical Information
Molecular Weight 506.34
Formula C21H17BrFN3O4S
CAS Number 1222878-02-5
Solubility (25°C) DMSO: ≥5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] James C Tarr, et al. Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169

[2] Christian Wenning, et al. Left ventricular dilation and functional impairment assessed by gated SPECT are indicators of cardiac allograft vasculopathy in heart transplant recipients

[3] Thomas M Bridges, et al. Discovery and development of a second highly selective M 1 Positive Allosteric Modulator (PAM)

[4] Paul R Reid, et al. Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe

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