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ML-9 is a potent, selective Akt kinase inhibitor that inhibits myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. It acts on MLCK, PKA and PKC with Ki values of 4, 32 and 54 μM, respectively. In addition, ML-9 induces autophagy by stimulating the formation of autophagosomes and inhibiting their degradation.
| Molecular Weight | 361.29 |
| Formula | C15H17N2O2SCl · HCl |
| CAS Number | 105637-50-1 |
| Solubility (25°C) | ethanol 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] G Inoue, et al. Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes
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