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ML-792 is a potent and selective SAE inhibitor with nanomolar potency in cellular assays. ML-792 inhibits SAE/SUMO1 and SAE/SUMO2 potently and selectively in enzymatic assays with IC50s of 3 and 11 nM, respectively. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Moreover, Induction of the MYC oncogene increased the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors. ML-792 provides rapid loss of endogenously SUMOylated proteins, thereby facilitating novel insights into SUMO biology.
| Molecular Weight | 551.41 |
| Formula | C21H23BrN6O5S |
| CAS Number | 1644342-14-2 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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