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In vitro: ML-7 hydrochloride inhibits rabbit portal vein α1-adrenoceptor NSCC with IC50 of 0.8 μM. The myosin light chain kinase (MLCK) inhibitor ML-7 hydrochloride (3 μ M and 10 μM) also attenuates the Dexmedetomidine (DMT)-induced contraction (p<0.05 versus control).
In vivo: In sham operated animals Evans Blue extravasation is not different between ML-7 hydrochloride and vehicle group (sham+vehicle: 0.26±0.02 OD/g; sham+ML-7: 0.26±0.02 OD/g). After CCI inhibition of MLCK with ML-7 results in a significant lower amount of intracerebral Evans Blue compared to vehicle treated animals (CCI+vehicle: 0.42±0.04 OD/g; CCI+ML-7: 0.35±0.05 OD/g, p=0.048)
Vet Microbiol. 2025 Mar 26;304:110494.
JEV NS1'protein enhances cell-to-cell viral spread by inducing the formation of tunneling nanotubes
ML-7 hydrochloride purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | MCF-10A cells, MDCK cells |
| Preparation method | Cells are treated with vehicle alone, Blebbistatin, ML-7, ML-9, latrunculin A or Y-27632 in media without serum at varying concentrations and time points before being fixed or prepared for FACS analysis. Untreated cells are also serum starved for the duration of the inhibitor treatment. Stock solutions of each agent are made in DMSO (50 μM Blebbistatin, 5 mM LA), 50% ethanol (10 mM ML-7), 70% ethanol (20 mM ML-9) or water (20 mM Y-27632) and are maintained at -20°C. |
| Concentrations | 40 μM |
| Incubation time | 16 h |
| Animal Experiment | |
|---|---|
| Animal models | Mice |
| Formulation | distilled water |
| Dosages | 1 mg/kg |
| Administration | i.p. |
| Molecular Weight | 452.74 |
| Formula | C15H18ClIN2O2S |
| CAS Number | 110448-33-4 |
| Solubility (25°C) | DMSO 40 mg/mL Water 1 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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