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ML 289 is a selective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.
| Molecular Weight | 349.42 |
| Formula | C22H23NO3 |
| CAS Number | 1382481-79-9 |
| Solubility (25°C) | DMSO 34.94 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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