All AbMole products are for research use only, cannot be used for human consumption.
Ml-210 is a selective, covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. Ml-210 binds GPX4 selenocysteine residues. ML210 has anticancer activity and has shown cytotoxic effects on melanoma, lung adenocarcinoma, fibrosarcoma and pancreatic cancer cell lines.
Mol Cell. 2024 Sep 14.
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer
ML 210 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | HCT8/V |
| Preparation method | Cells were seeded at 5 × 10^4/well in 12-well plates and pretreated with ML210 3 μM, 10 μM or Verapamil 10 μM for 1 h. |
| Concentrations | 3 μM |
| Incubation time | 1 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 475.32 |
| Formula | C22H20Cl2N4O4 |
| CAS Number | 1360705-96-9 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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