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ML-184

Cat. No. M55658

All AbMole products are for research use only, cannot be used for human consumption.

ML-184 Structure
Synonym:

CID2440433; ML184

Size Price Availability Quantity
5mg USD 160 In stock
10mg USD 260 In stock
25mg USD 440 In stock
50mg USD 620 In stock
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Quality Control & Documentation
Biological Activity

ML-184 (CID2440433) is a selective GPR55 agonist with an EC50 of 250 nM and exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-184(CID2440433) increases proliferation of neural stem cells and promotes neuronal differentiation in vitro. ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.

Chemical Information
Molecular Weight 470.63
Formula C25H34N4O3S
CAS Number 794572-10-4
Solubility (25°C) DMSO 10 mg/mL
DMF 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jeremy D Hill, et al. Br J Pharmacol. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis

[2] Evangelia Kotsikorou, et al. Biochemistry. Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands

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Keywords: ML-184, CID2440433; ML184 supplier, GPR/FFAR, inhibitors, activators

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