All AbMole products are for research use only, cannot be used for human consumption.
ML-18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). ML-18 binds with lower affinity to the GRPR and NMBR with IC50 values of 16 and more than 100 μM, respectively. ML-18 at 16 μM inhibits the ability of 100 nM BA1 to cause tyrosine phosphorylation of the EGFR and ERK in lung cancer cells.
| Cell Experiment | |
|---|---|
| Cell lines | NCI-H727 or NCI-H1299 cells |
| Preparation method | NCI-H727 or NCI-H1299 cells transfected with BRS-3 are treated with ML-18 (0, 4.8, 16, 48 μM) or gefitinib added. After 2 days, 15 μL of 0.1 % MTT solution added. After 4 h, 150 μL of DMSO is added. After 16 h, the optical density at 570 nm is determined. |
| Concentrations | 0, 4.8, 16, 48 μM |
| Incubation time | 2 days |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 569.65 |
| Formula | C32H35N5O5 |
| CAS Number | 1422269-30-4 |
| Form | Solid |
| Solubility (25°C) | DMSO: ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Bombesin Receptor Products |
|---|
| MK-5046
MK-5046 is an orally active, potent, selective agonist of the orphan G protein-coupled receptor bombesin receptor subtype-3 (BRS-3) that is under evaluation for treatment of obesity. |
| Kuwanone H
Kuwanone H |
| Bombesin
Bombesin is a tetradecapeptide, which plays an important role in the release of gastrin and the activation of G-protein receptors. |
| Ranatensin
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, which could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide, Bradykinin, or Norepinephrine. |
| RC-3095 TFA
RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
