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MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50 of 0.14 μM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth.
| Molecular Weight | 361.35 |
| Formula | C18H19NO7 |
| CAS Number | 1338934-59-0 |
| Solubility (25°C) | DMSO 6 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IRE1 Products |
|---|
| 4μ8C
4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
| STF-083010
STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. |
| KIRA6
KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM. |
| MKC-3946
MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
| Kira8
Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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