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MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM. MK2-IN-3 inhibits TNFα production in U937 cells, with IC50 of 4.4 μM, respectively. MK2-IN-3 (20 mg/kg; a single p.o. before LPS challenge) inhibits 20% TNFα production in rat LPS (rLPS) model.
Invest New Drugs. 2025 Mar 17;43(2):301-310.
Evaluation of the anti-leukemia activity and underlying mechanisms of the novel perinucleolar compartment inhibitor CTI-2 in acute myeloid leukemia
MK2 Inhibitor III purchased from AbMole
| Molecular Weight | 340.38 |
| Formula | C21H16N4O |
| CAS Number | 724711-21-1 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | -20°C, protect from light |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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